C7522
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C7522
Sigma
Calcium Ionophore A23187
≥98% (TLC), powder
| Synonym: | Antibiotic A 23187, Calimycin |
| CAS Number: | 52665-69-7 |
| Linear Formula: | C29H37N3O6 |
| Molecular Weight: | 523.62 |
| Beilstein Registry Number: | 1096801 |
| EC Number: | 258-084-1 |
| MDL number: | MFCD00151202 |
| PubChem Substance ID: | 24277964 |
Description
| Application | Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. |
Properties
| assay | ≥98% (TLC) |
| form | powder |
| color | white to light yellow |
| solubility | ethanol: 5 mg/mL with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination. |
| DMSO: 50 mg/mL with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination. | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DM4676000 |
References
| reference | Pressman, B.C., et al., Biological applications of ionophores. Annu. Rev. Biochem. 45, 50-530, (1976) |
| Kauffman, R.F., et al., Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J. Biol. Chem. 255, 2735-2739, (1980) | |
| Markram, H., and Segal, M., Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Brain Res. 540, 322-324, (1991) | |
| Knowles, R.G., and Moncada, S., Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17, 399-402, (1992) | |
| Merck | Merck 13,1639 |
